Cycling effect on EPC to risk of cardiovascular disease in geriatry: systematic review


  • Farida Murtiani RSPI Prof Dr Sulianti Saroso
  • Upik Rahmi Program Studi DIII Keperawatan, Fakultas Pendidikan Olahraga dan Kesehatan, Universitas Pendidikan Indonesia
  • Septian Andriyani Program Studi DIII Keperawatan, Fakultas Pendidikan Olahraga dan Kesehatan, Universitas Pendidikan Indonesia
  • Suci Tuty Putri Program Studi DIII Keperawatan, Fakultas Pendidikan Olahraga dan Kesehatan, Universitas Pendidikan Indonesia
  • Lisna Annisa Fitriana Program Studi DIII Keperawatan, Fakultas Pendidikan Olahraga dan Kesehatan, Universitas Pendidikan Indonesia



Cycling, Endothelial Progenitor Cell, Physical Activity, Cardiovascular


This systematic review aims to review published articles on the effects of physical activity (PA) cycling on biomarkers of endothelial cell function on the risk of cardiovascular disease. Studies involving angiogenic factors were searched in the Medline and Cochrane libraries. Native human studies over 2 weeks of PA intervention were included. Study quality was assessed according to the GRADE evidence system. Results: five complete articles according to the inclusion criteria. Cycling increases angiogenic, endothelial progenitor cells (EPC) and decreased VEGF. The effect of PA on this factor appears to depend on the type and duration of exercise intervention and patient factors, such as the presence of ischemia. As presented in this review, there is strong evidence that cycling physical activity positively affects endothelial cell function and determines the risk of carciovascular disease.


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How to Cite

Murtiani F, Rahmi U, Andriyani S, Tuty Putri S, Annisa Fitriana L. Cycling effect on EPC to risk of cardiovascular disease in geriatry: systematic review. J Keskom [Internet]. 2023 Jul. 26 [cited 2024 Feb. 27];9(2):213-20. Available from: